Hazlewood, who has taken 295 wickets in 76 Tests, was limited to only one appearance in Australia’s last home Ashes four years ago because of a side injury.
While Cummins is thought to be on track to play in the second Test in Brisbane, where he would reclaim the captaincy from Steve Smith, there is no indication of Hazlewood’s status beyond Perth.
A statement from Australia said: “Josh Hazlewood underwent repeat imaging that has confirmed a hamstring strain injury.
“Initial scans on Wednesday were clear of muscle strain, however follow-up imaging has confirmed the injury. Early imaging can occasionally underestimate low-grade muscle injuries.
“As a result, Hazlewood will not travel to Perth and has been ruled out of the first Ashes Test match.”
Along with Cummins, back-up seamer Sean Abbott had already been ruled out of the first Test because of his own hamstring injury.
Spencer Johnson and Lance Morris, both capable of high pace, are long-term absentees.
Neser, already in Perth after playing in the Sheffield Shield for Queensland in the past week, gets the call ahead of Fergus O’Neill.
Jhye Richardson, who won the last of his three Test caps against England four years ago, is another option later in the series after recovering from shoulder surgery.
Richardson will continue his comeback for a Cricket Australia XI against England Lions next weekend.
